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Scientific Board: F. Di Raimondo – G. A. Palumbo
Scientific Secretariat: A. Chiarenza – M. Di Rosa- C. Giallongo – A. Romano- D. Tibullo – N. Vicario
Data svolgimento: 5-6 Novembre 2021
Sede: Catania, Aula Magna Torre Biologica Università degli Studi di Catania
Descrizione Corso:
Negli ultimi anni la medicina personalizzata e l’immunoterapia hanno migliorato la gestione clinica delle maggiori neoplasie ematologiche (mieloma multiplo, linfomi, leucemia linfatica cronica, mielofibrosi, leucemie acute). L’utilizzo di nuove tecniche di imaging e di modelli preclinici ha favorito la rapida traslazione in clinica delle conoscenze sviluppate, per cui diventa necessario per i
ricercatori integrare interessi sviluppati nell’ambito di differenti discipline.
Le due giornate di approfondimento, rivolte a medici, infermieri, biologi e biotecnologi, hanno lo scopo di integrare le più innovative tecnologie disponibili per lo sviluppo di modelli preclinici con le applicazioni cliniche delle nuove scoperte, in modo da ridurre la distanza tra il laboratorio – the benchside- e la corsia – the bedside.
Programma:
Friday, November 5, 2021
12:00 Registration of Participants
Welcome lunch
Greeting from the Authorities
Introduction
F. Di Raimondo (Catania)
I SESSION
Novel means to treat Multiple Myeloma
Chairmen: F. Di Raimondo (Catania), U. Consoli (Catania)
14:00 The clonal evolution of Multiple Myeloma: implications for guiding
personalized medicine
A. Neri (Milano)
14:20 How novel proteasome inhibitors will change the treatment of relapsed and refractory Multiple Myeloma patients
P. Musto (Bari)
14:40 Targeting CD38 and BCMA: how immunotherapy will change the first-line treatment of Multiple Myeloma
N. Giuliani (Parma)
15:00 Discussion on the above topics – All Teachers
II SESSION
Novel means to understand multiple myeloma
Chairmen: C. Conticello (Catania), R. Parenti (Catania)
15:10 Integrated functional genomic approach reveals an emerging role of lncRNA NEAT1 in drug resistance in multiple myeloma
E. Taiana (Milano)
15:30 Role of TLR4 signalling in Multiple Myeloma
G. Scandura (Catania)
15:50 Role of JAM-A in the microenvironment dysregulation of Multiple Myeloma
A.G. Solimando (Bari)
16:05 How to track microenvironment dysregulation in Multiple Myeloma: implications for guiding personalized medicine
C. Botta (Palermo)
16:25 Discussion on the above topics – All Teachers
16:35 Coffee Break
III SESSION
Novel means to understand and treat Lymphoproliferative Disorders
Chairmen: M. Gentile (Cosenza), M. Massaia (Cuneo)
17:00 Targeting CD30: how immunotherapy will change the therapeutic scenario for T-cell lymphoma
A. Broccoli (Bologna)
17:20 Emerging target therapy in Chronic Lymphocytic Leukemia
A. Chiarenza (Catania)
17:40 Minimal residual disease in Chronic Lymphocytic Leukemia: a new goal?
I. Del Giudice (Roma)
18:00 Discussion on the above topics – All Teachers
IV SESSION
Novel means to understand and treat Lymphoproliferative Disorders
Chairmen: V. Gattei (Aviano), R. Cacciola (Catania)
18:10 Microenvironmental dysregulation in diffuse large B cell lymphoma
S. Ciavarella (Bari)
18:30 TP53 disruption under ibrutinib: more is worse?
R. Bomben (Aviano)
18:50 How to integrate multi-level information in mantle cell lymphoma:
a Dynamics Systems Thinking approach
A. Romano (Catania) and F. Gonella (Venezia)
19:10 Discussion on the above topics – All Teachers
19:30 Conclusions
Saturday, November 6, 2021
I SESSION
Perspectives for diagnosis and treatment of Myeloid Neoplasms
Chairmen : F. Stagno (Catania), G. Li Volti (Catania)
09:00 Lecture: Chronic Myeloid Leukemia: new challenges in 2022
C. Gambacorti Passerini (Milano)
09:45 Novel strategies in myelofibrosis treatment: JAK inhibitors and beyond
S. Galimberti (Pisa)
10:05 Novel pathogenetic mechanisms for Myeloproliferative Neoplasms
A. Balduini (Pavia)
10:25 Lactate orchestrates tumor microenvironment remodeling and rewires
metabolic profile in myelofibrosis
D. Tibullo (Catania)
10:45 Discussion on the above topics – All Teachers
11:00 Coffee Break
II SESSION
Novel means to understand and treat Myeloid Neoplasms
Chairmen: G. Palumbo (Catania), G. Lazzarino (Roma)
11:30 Integrated genomic-metabolic classification of acute myeloid leukemia
G. Simonetti (Meldola)
11:50 How to unveil target vulnerabilities in acute myeloid leukemia
M. P. Martelli (Perugia)
12:10 Interplay between metabolism and epigenetics in tumor reprogramming of mesenchymal stromal cells in myelodysplastic syndrome
C. Giallongo (Catania)
12:30 New models for deciphering abnormal hematopoiesis in vivo
M.C. Mione (Trento)
12.50 Role of IGFBP6 in immune evasion in hematological neoplasms
A. Liso (Foggia)
13:15 Discussion on the above topics – All Teachers
13:30 Light lunch
III SESSION
Workshop: a practical guide to manage innovation
15:30 (first come, first served) in five parallel sessions:
Photoacoustic imaging and biophysical images in mice
Tutors: C. Giallongo (Catania) and N. Vicario (Catania)
Photoacoustic imaging and biophysical images in zebrafish
Tutors: D.Tibullo (Catania) and M. Di Rosa (Catania)
How to build up a systems thinking diagram
Tutors: A. Romano (Catania) and M. Casazza (Napoli)
Publish or perish: an Editorial perspective
Tutor: N. Amodio (Catanzaro) and Cerchione (Meldola)
From bench to bedside: the FIL experience
Tutors: I. Del Giudice (Roma) V. Gattei (Aviano)
17:30 Discussion on the above topics – All Teachers
18:00 Conclusions
F. Di Raimondo (Catania)
Learning test
12
Medico chirurgo: Ematologia, Medicina interna, Oncologia, Chirurgia generale, Anatomia patologica, Medicina nucleare, Microbiologia e virologia, Patologia clinica (laboratorio di analisi)
Biologo: Biologo
Tecnico sanitario laboratorio biomedico: Tecnico sanitario laboratorio biomedico
